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Linear growth velocity may be as slow as ...

Linear growth velocity may be as slow as 3 cm per year and growth velocity of < 4 to 5 cm per year is common. A significant number of these affected children fail to undergo puberty at the appropriate age unless treated. Children treated properly with human growth hormone (HGH) supplementation are capable of achieving 5-10cm per year growth. Diagnosis of GHD in children is often straightforward with a reduced linear growth velocity and the maximal growth hormone value of provocation of less than 7 ng/ml. A provocation value in excess of 10 ng/ml excludes the diagnosis of growth GHD. The treatment of GHD with HGH in children has not been linked to any oncogenic potential.

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