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Since aging is a multifactorial neuro-endocrine disorder ...

Since aging is a multifactorial neuro-endocrine disorder, multiple hormone deficiencies coexist. Each of the hormonal systems has to be evaluated independently with laboratory and clinical biomarkers. Direct measurement of growth hormone level does pose a significant challenge because of its pulsatile nature. Plasma Insulin Growth Factor 1 (IGF-1) level concentrations decline with advancing age in healthy adults paralleling the growth hormone decline. After a great deal of debate, a consensus has been reached to use IGF-1 as an indirect marker for growth hormone level.

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